On weekends (Friday and Saturday), nightlife in Cagayan de Oro bustles. Bars usually open around 7 pm but the crowds usually come in around 10 or 11 pm. Most bars close by 3 in the morning. During weekdays, most bars close by midnight. Not many people go out on weekdays.

The Rosario Arcade or Rosario Strip in Limketkai Center is a favorite watering hole for young urbanites and the young at heart.  High-end bars, coffee shops and restaurants are located in this area. 

Divisoria vicinity (Downtown) is quite festive in the late evenings. Parks in Divisoria are filled with vendors and massage therapists.  During Friday and Saturday, Divisoria is closed to vehicular traffic for the weekend Night Café and Market.

There are also a concentration of restaurants, bars and hotels along the streets of Tiano corner Kalambaguhan and Tiano corner Del Pilar.

Gas stations in the city are popular hang-out spots for car and motorcycle users.  The most popular are Caltex Station along Gusa Highway, A. Velez Street and Kauswagan Highway.